Ternary complex of DNA Polymerase Beta with a gapped DNA containing 8odG at template position paired with non-hydrolyzable dCTP analog (dCMP(CF2)PP)
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Ternary complex of DNA Polymerase Beta with a gapped DNA containing 8odG at template position paired with non-hydrolyzable dCTP analog (dCMP(CF2)PP) Descriptor: 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Batra, V.K, Beard, W.A, Wilson, S.H. Deposit date: 2011-04-15 Release date: 2012-01-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Binary complex crystal structure of DNA polymerase beta reveals multiple conformations of the templating 8-oxoguanine lesion Proc.Natl.Acad.Sci.USA, 109, 2012
携带模板位点含8-氧代鸟嘌呤(8odG,又称8OG)缺口DNA与非水解性dCTP类似物(dCMP(CF₂)PP)结合的DNA聚合酶β(DNA Polymerase Beta)三元复合物
描述项:2'-脱氧-5'-O-[(S)-{二氟[(S)-羟基(膦酰氧基)膦酰基]甲基}(羟基)膦酰基]胞苷、氯离子、DNA序列(5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'),……
作者:Batra V.K.、Beard W.A.、Wilson S.H.
提交日期:2011-04-15
发布日期:2012-01-18
最后修改日期:2023-09-13
实验方法:X射线衍射(分辨率2.3埃)
引用文献:《DNA聚合酶β的二元复合物晶体结构揭示模板8-氧代鸟嘌呤损伤的多种构象》,《美国国家科学院院刊》,109卷,2012年
创建时间:
2011-04-15



