Cryo-EM structure of a delivery complex containing the SspB adaptor, an ssrA-tagged substrate, and the AAA+ ClpXP protease
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Cryo-EM structure of a delivery complex containing the SspB adaptor, an ssrA-tagged substrate, and the AAA+ ClpXP protease Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... Authors: Ghanbarpour, A, Fei, X, Davis, J.H, Sauer, R.T. Deposit date: 2022-10-16 Release date: 2023-01-25 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery. Proc.Natl.Acad.Sci.USA, 120, 2023
包含SspB衔接蛋白(SspB adaptor)、带有ssrA标签的底物(ssrA-tagged substrate)以及AAA+ ClpXP蛋白酶(AAA+ ClpXP protease)的递送复合物冷冻电镜(Cryo-EM)结构 成分说明:腺苷-5'-二磷酸(ADENOSINE-5'-DIPHOSPHATE)、ATP依赖型Clp蛋白酶ATP结合亚基ClpX、ATP依赖型Clp蛋白酶蛋白水解亚基…… 作者:Ghanbarpour, A、Fei, X、Davis, J.H、Sauer, R.T. 提交日期:2022-10-16 发布日期:2023-01-25 最后修改日期:2024-06-19 实验方法:电子显微镜(ELECTRON MICROSCOPY),分辨率3.7 Å 引用文献:SspB衔接蛋白在带有ssrA标签的底物递送过程中诱导AAA+ ClpXP蛋白酶发生构象变化。美国国家科学院院刊(Proc.Natl.Acad.Sci.USA),120卷,2023年



