Proteasome degradative activity regulates CD8+ T lymphocyte metabolism and fate specification

Pre-effector and pre-memory cells resulting from the first CD8+ T cell division in vivo exhibit low and high rates of proteasome degradative activities, respectively. These proteasome-induced metabolic consequences were mediated in part by asymmetric segregation of Myc during cell division. Taken together, these results suggest proteasome activity as a regulator of CD8+ T lymphocyte metabolism and fate specification. Transcriptome of biological duplicates of isolated CD8+CD44+ mouse lymphocytes treated with vehicle control, proteasome inhibitor, and proteasome activator were analyzed.