Text S1 - Synapse Geometry and Receptor Dynamics Modulate Synaptic Strength

Presents the following information: In Section 1, the derivation of the formula for the PSD-reservoir receptor exchange rates. In Section 2, additional data for Figure 2 regarding synaptic geometry with the JS and MN AMPAR models, and for uniformly distributed release sites. In Section 3, additional data for Figure 3 regarding glutamate spread for doubled glutamate diffusion constant. In Section 4, further comments on AMPAR trafficking and synaptic transmission. In Section 5, comments on the effect of reservoir size on pulse trains. In Section 6, JS, MN, and RL AMPAR kinetic models are compared. Section 7 provides a detailed simulation analysis and description of algorithms. (PDF)