Human Angiotensin-1 converting enzyme C-domain in complex with a diprolyl inhibitor- SG16

Human Angiotensin-1 converting enzyme C-domain in complex with a diprolyl inhibitor- SG16 Descriptor: (2~{S})-1-[(2~{S})-2-[[(1~{S})-1-[(2~{S})-1-[(2~{S})-2-azanyl-4-oxidanyl-4-oxidanylidene-butanoyl]pyrrolidin-2-yl]-2-oxidanyl-2-oxidanylidene-ethyl]amino]propanoyl]pyrrolidine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gregory, K.S, Cozier, G.E, Acharya, K.R. Deposit date: 2024-07-31 Release date: 2025-01-22 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds. Febs J., 292, 2025

人血管紧张素-1转换酶（Human Angiotensin-1 converting enzyme）C结构域与二脯氨酰类抑制剂SG16的复合物。描述符：(2S)-1-[(2S)-2-[[(1S)-1-[(2S)-1-[(2S)-2-氨基-4-羟基-4-氧代丁酰基]吡咯烷-2-基]-2-羟基-2-氧代乙基]氨基]丙酰基]吡咯烷-2-羧酸；2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等组分；作者：Gregory K.S.、Cozier G.E.、Acharya K.R.；提交日期：2024年7月31日；发布日期：2025年1月22日；最后修改日期：2025年3月19日；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å）；引用文献：《系列二脯氨酰类衍生物抑制人血管紧张素-1转换酶的分子机制》，《FEBS杂志》（Febs J.），第292卷，2025年