Combined Proteomics and Transcriptomics Identifies Serpin Family C Member 1 Associated Protein as a Biomarker of Endometriosis

Objective: To explore potential biomarkers indicating endometriosis. Results: A sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the endometriosis cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e., fetuin B and serpin family C member 1; the latter showed a big variance between the control category and the EM set in the authentication test. Conclusion: Serpin family C member 1 may be a useful possible biomarker for the analysis of EM. Materials and methods: A proteomics method and combined quantitative transcriptomics was adopted to highlight markers in the Endometriosis (EM). Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay.