Incidence, onset time and seriousness of adverse drug reactions due to directly observed treatment strategy therapy in 4304 Chinese tuberculosis patients.

IQR, inter-quartile range.#The incidence of ADR was standardized for age and gender with direct standardization using one reference population that from national TB epidemic surveillance database of 2008.†It was from initiation of treatment.§Serious ADRs were defined as any untoward medical occurrence that at any dose results in death, requires hospital admission or prolongation of existing hospital stay, results in persistent or significant disability/incapacity, or is life threatening.$It was the time that ADRs were found, not the exact time it happened.‡Nervous system disorders included auditory nerve damage, optic nerve damage, peripheral nervous damage and central nervous system damage.€Others included one with interstitial pneumonia and another with hypokalemia.*For 82 patients got two ADRs, sixteen got three and one got four, 766 cases were detected and the denominator was 4304+82+32+3 = 4421.