GSNO-R activity measured by modified Saville Assay is greater in lung homogenates obtained from female mice.

GSNO-R activity was determined in homogenates from the lung, liver and kidney of adult male and female mice. GSNO-R activity was measured in homogenates (250 µg) in the presence of 100 µM GSNO in the presence or absence of NADH at 37°C for 5 min. GSNO-R activity was significantly higher in lung homogenates obtained from female mice compared to male mice (n = 4). No gender specific differences were seen in either the liver or kidney homogenates (n = 2–4).