Additional file 3: of Association of four imprinting disorders and ART

Clinical characterization of ART-patients. OI/TI, ovulation induction/timed intercourse; IUI, intrauterine insemination; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection. N.A. indicates that data was not available. Clinical features were as follows, 1. Macroglossia, 2. Earlobe creases, 3. Umbilical hernia, 4. Hemihypertrophy, 5. Exomphalos, 6. Exophthalmos, 7. Hepatomegaly, 8. Nephromegaly, 9. Ocular hypertelorism, 10. Cryptorchism, 11. Occlusal interference, 12. Mental retardation, 13. Epilepsy, 14. Dysphasia, 15. Dyschromatosis, 16. Ictal laughter, 17. Prognathism, 18. Hyposomnia, 19. Convulsions, 20. Microcephaly, 21. Hypotonia, 22. Feeding difficulties, 23. Almond-shaped eyes, 24. Short stature, 25. Triangular mouse, 26. Acromicria, 27. Bulimia, 28. Obesity, 29. Hypogonadism, 30. Diabetes, 31. Gastrointestinal injury, 32. Cardiac failure, 33. Failure to thrive, 34. Triangular-shaped face, 35. Body asymmetry, 36. Clinodactyly of the fifth fingers, 37. Sweating, 38. Heart malformation. 39. Tumorigenesis. (XLSX 12 kb)

辅助生殖技术（Assisted Reproductive Technology, ART）患者的临床特征描述。其中OI/TI指诱导排卵/定时同房（ovulation induction/timed intercourse）；IUI指宫腔内人工授精（intrauterine insemination）；IVF指体外受精（in vitro fertilization）；ICSI指卵胞浆内单精子注射（intracytoplasmic sperm injection）。N.A.表示数据不可用。本次纳入的临床特征如下：1. 巨舌症，2. 耳垂褶皱，3. 脐疝，4. 偏侧肥大，5. 脐膨出，6. 突眼症，7. 肝肿大，8. 肾肿大，9. 眼距过宽，10. 隐睾症，11. 咬合干扰，12. 智力障碍，13. 癫痫，14. 言语障碍，15. 色素异常，16. 发作性发笑，17. 颌前突，18. 睡眠减少，19. 惊厥，20. 小头畸形，21. 肌张力低下，22. 喂养困难，23. 杏仁眼，24. 身材矮小，25. 三角嘴，26. 肢端短小，27. 贪食症，28. 肥胖症，29. 性腺功能减退，30. 糖尿病，31. 胃肠道损伤，32. 心力衰竭，33. 生长发育迟缓，34. 三角脸，35. 躯体不对称，36. 第五指屈曲畸形，37. 多汗，38. 心脏畸形，39. 肿瘤发生。（XLSX格式，文件大小12千字节）