M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 45 (VCC117054)
收藏Protein Data Bank Japan2023-10-04 更新2026-03-21 收录
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M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 45 (VCC117054) Descriptor: (2S)-N-(2H-1,3-benzodioxol-5-yl)-4-[(isoquinolin-5-yl)sulfonyl]-2-methylpiperazine-1-carboxamide, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase Authors: Ascher, D.B, Pacitto, A, Blundell, T.L. Deposit date: 2018-04-18 Release date: 2019-05-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. Eur.J.Med.Chem., 174, 2019
耐热分枝杆菌（M. thermoresistible）GuaB2 delta-CBS与抑制剂Compound 45（VCC117054）的复合物。描述符：(2S)-N-(2H-1,3-苯并二氧戊环-5-基)-4-[(异喹啉-5-基)磺酰基]-2-甲基哌嗪-1-甲酰胺、肌苷酸（INOSINIC ACID）、肌苷-5'-单磷酸脱氢酶(Inosine-5'-monophosphate dehydrogenase)。作者：Ascher, D.B.、Pacitto, A.、Blundell, T.L.。沉积日期：2018-04-18；发布日期：2019-05-01；最后修改日期：2023-10-04。实验方法：X射线衍射（X-RAY DIFFRACTION，波长1.54 Å）。引用文献：《1-(5-异喹啉磺酰基)哌嗪类衍生物作为结核分枝杆菌IMPDH抑制剂的合成及其构效关系》，《欧洲医药化学杂志》（Eur.J.Med.Chem.），第174卷，2019年
创建时间：
2018-04-18
