Synthesis and crystal structure of a new Zn(II) complex with anti-leukemia activity

A new Zn(II)-containing coordination complex [ZnBrL] (<b>1</b>) based on the Schiff base ligand(E)-1-(((3-(piperidin-1-yl)propylidene)amino)methyl)naphthalen-2-ol (HL) has been successfully prepared using a slow volatilization method. A mechanical grinding method was applied for preparing the crystalline complex <b>1</b> in the nano-region, which was studied by both of the scanning electron microscopy and transmission electron microscopy. In addition, its inhibitory effect on ARH-77 human leukemia cells were evaluated. First, the Cell Counting Kit-8 detection kit was used to detect the influence of nano <b>1</b> on the cell viability. Next, the cell colony formation assay was conducted for the determination of the cell proliferation. The trans-well assay was performed to explore the migration and invasion of the cells after nano <b>1</b> treatment.