Assesing DNA methylation patterns of human cortical organoids during long term (>600 days) maturation. 52 samples collected during long term maturation of human cortical spheroids
Purpose:The primary cilia play central roles in transducing or regulating various signaling pathways during brain development. However, the function of primary cilia in mature nerve system is currentl
How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain development is largely unknown. Here, we combined single-cell RNA-seq and single-cell ATAC-seq with cell-typ
The proliferative niches in the subpallium generate a rich cellular variety fated for diverse telencephalic regions. The embryonic preoptic area (POA) represents one of these domains giving rise to th
Activation of the embryonic genome is a crucial step in development. In addition to thousands of genes, many transposable elements (TEs) are robustly transcribed during early mammalian development. Ho
