Whole-Transcriptome Analysis in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients and Healthy controls

To identify expression quantitative trait loci (eQTLs) that could be implicated in Multiple Sclerosis (MS) etiology or disease course, we performed a genome-wide eQTL analysis using genome-wide SNPs data and transcriptome-wide mRNA expression data. We generated expression profile of mRNA in peripheral blood mononuclear cells (PBMCs) from MS patients with different disease course and healthy controls. We included a total of 36 MS patients 20 with mild and 16 sever course of the disease as well as 19 healthy controls.