Efficacy of 100 hz sound stimulation on saccular dysfunction in meniere’s disease

Although various medical remedies have been attempted to alleviate the symptoms of Meniere’s disease (MD), the risk–benefit ratios of these various treatments remain debatable. We investigated the efficacy of sound stimulation of 100 Hz for treating vestibular dysfunction in patients with Meniere’s disease (MD). Patients with definitive MD with intractable vestibular symptoms and endolymphatic hydrops (EH) in the inner ear were evaluated. The experimental group received sound stimulation of 75 dB at a frequency of 100 Hz for 5 min, and the control group received sound stimulation of 75 dB at a frequency of 250 Hz for 5 min. Cervical vestibular-evoked myogenic potentials (cVEMPs) were measured before and after each sound stimulation, and the results of the clinical tests were compared between the two patient groups. Significant increases in cVEMP amplitudes were observed after sound stimulation of 100 Hz in ears with vestibular endolymphatic hydrops, although no such improvement was observed in the control group. Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cVEMP amplitude in patients with definitive MD. Adequate sound stimulation might be a new method for treating vestibular dysfunction associated with MD.

尽管目前已有多种医疗手段被尝试用于缓解梅尼埃病（Meniere’s disease, MD）的临床症状，但各类治疗方案的风险收益比仍存在诸多争议。本研究旨在探究100Hz声刺激治疗梅尼埃病患者前庭功能障碍的临床疗效。本研究纳入经确诊的梅尼埃病患者，且均伴有难治性前庭症状及内耳内淋巴积水（endolymphatic hydrops, EH）。实验组接受频率为100Hz、声压级75dB的声刺激，刺激时长5分钟；对照组则接受频率为250Hz、声压级75dB的声刺激，刺激时长同样为5分钟。分别于每次声刺激前后采集颈前庭诱发肌源性电位（cervical vestibular-evoked myogenic potentials, cVEMPs），并对两组患者的临床检测结果进行对比分析。结果显示，伴前庭内淋巴积水的患耳在接受100Hz声刺激后，其颈前庭诱发肌源性电位波幅出现显著升高，而对照组未观察到类似的改善效果。综上，频率100Hz、声压级75dB的声刺激可有效提升确诊梅尼埃病患者的颈前庭诱发肌源性电位波幅，适当的声刺激或许可成为治疗梅尼埃病相关前庭功能障碍的新型干预手段。