Transcriptional response of human synovial fibroblasts to TNF and IL-17A

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series: Microarray Data 1 (n=60) 9 time points, 2 technical replicates, 5 stimulations (Untreated; Media; IL-17A (1 ng/mL); TNF (1 ng/mL); TNF and IL-17A) Microarray Data 2 (n=48) 1 time point (24 hours), 3 passages, 4 cell lines, 4 stimulations (Baseline; None; TNF; TNF and IL-17A) RNA-seq Data 1 (n=175) 7 synovial fibroblast cell lines from patient tissues, 9 time points (0, 2, 4, 6, 8, 10, 12, 18, and 24 hours), 3 stimulations (TNF (1 ng/mL); TNF (1 ng/mL) and IL-17A (1 ng/mL); TNF (1 ng/mL) and IL-17A (10 ng/mL)) RNA-seq Data 2 (n=192) 4 synovial fibroblast cell lines from patient tissues, 4 time points (0, 1, 6 and 16 hours), 2 stimulations (TNF (0.1 ng/mL); TNF (0.1 ng/mL) and IL-17A (1 ng/mL)), and 5 siRNAs (CUX1, LIFR, STAT3, STAT4, ELF3)