Integrative transcriptomics reveals activation of innate immune responses and inhibition of inflammation during oral immunotherapy for egg allergy in children

The objective of the study was to investigate how oral immunotherapy (OIT) for food allergy modulates inflammation and immune cell responses. The blood cell transcriptome of 50 children receiving egg OIT was profiled using peripheral blood mononuclear cell (PBMC) samples obtained at baseline and after 3 and 8 months of OIT. Venous blood samples were collected from 50 egg allergic children at the baseline (L0), after 3 months (L2) or after 8 months (L3) of OIT with increasing consumption of egg, PBMCs were separated and totRNA extracted for microarray analyses.