Phosphinamide-Directed Benzylic Lithiation. Application to the Synthesis of Peptide Building Blocks
收藏NIAID Data Ecosystem2026-03-06 收录
下载链接：
https://figshare.com/articles/dataset/Phosphinamide_Directed_Benzylic_Lithiation_Application_to_the_Synthesis_of_Peptide_Building_Blocks/2956072
下载链接
链接失效反馈官方服务：
资源简介：
N-Benzyldiphenylphosphinamides are deprotonated at the NCα position diastereospecifically upon treatment with t-BuLi in diethyl ether at low
temperature. The reaction of the anions with alkyl, acyl, and tin halides, aliphatic and aromatic aldehydes, and Michael acceptors allowed
installation of a variety of functional groups into the benzylic arm in excellent yields. Cleavage of the P−N linkage affords 1,2-amino alcohols
and α-, β-, and γ-amino acids.
创建时间：
2016-06-03
