SC2sepsis

Due to the fact that most sepsis-related studies utilizing scRNA-seq have very small sample sizes and there is a lack of an scRNA-seq database for sepsis, we developed Sepsis Single-cell Whole Gene Expression Database Website (SC2sepsis) (http://www.rjh-sc2sepsis.com/), integrating scRNA-seq datasets of human peripheral blood mononuclear cells from 45 septic patients and 26 healthy controls, with a total amount of 232 226 cells. SC2sepsis is a comprehensive resource database with two major features: (i) retrieval of 1988 differentially expressed genes between pathological and healthy conditions and (ii) automatic cell-type annotation, which is expected to facilitate researchers to gain more insights into the immune dysregulation of sepsis.鉴于目前多数利用单细胞RNA测序（single-cell RNA sequencing, scRNA-seq）开展的脓毒症相关研究样本量普遍较小，且缺乏针对脓毒症的scRNA-seq数据库，我们构建了脓毒症单细胞全基因表达数据库网站（SC2sepsis）（网址：http://www.rjh-sc2sepsis.com/）。该数据库整合了来自45名脓毒症患者与26名健康对照者的人类外周血单个核细胞scRNA-seq数据集，总计包含232226个细胞。SC2sepsis作为一款综合性资源数据库，具备两大核心功能：其一，可检索病理状态与健康状态间的1988个差异表达基因（differentially expressed genes）；其二，支持自动细胞类型注释。本数据库旨在助力研究人员更深入地解析脓毒症的免疫失调机制。

搜集汇总

背景与挑战

背景概述

SC2sepsis是一个针对脓毒症研究的单细胞RNA测序数据库，整合了来自45名患者和26名健康对照的超过23万个细胞数据。该数据库提供差异表达基因检索和自动细胞类型注释两大核心功能，旨在帮助研究人员深入理解脓毒症的免疫失调机制。