Distinct spread of DNA and RNA viruses among mammals amid prominent role of domestic species

Aim: Emerging infectious diseases arising from pathogen spillover from mammals to humans comprise a substantial health threat. Tracing virus origin and predicting the most likely host species for future spillover events are major objectives in One Health disciplines.

We assessed patterns of virus sharing among a large diversity of mammals, including humans and domestic species.

Location: Global.

Time period: Current.

Major taxa studied: Mammals and associated viruses.

Methods: We used network centrality analysis and trait-based Bayesian hierarchical models to explore patterns of virus sharing among mammals. We analysed a global database that compiled the associations between 1,785 virus species and 725 mammalian host species as sourced from automatic screening of meta-data accompanying published nucleotide sequences between 1950 – 2019.

Results: We show that based on current evidence, domesticated mammals hold the most central positions in networks of known mammal-viru...

研究目标：由哺乳动物向人类的病原体溢出引发的新发传染病，对人类健康构成重大威胁。溯源病毒起源、预测未来溢出事件的最可能宿主物种，是One Health（同一健康）学科的核心研究方向。

本研究针对包括人类与家养物种在内的多样哺乳动物类群，分析了病毒共享模式。

研究地域：全球范围

研究时段：当前（数据集覆盖1950年至2019年）

研究类群：哺乳动物及其关联病毒

研究方法：本研究采用网络中心性分析与基于性状的贝叶斯分层模型，探究哺乳动物间的病毒共享模式。我们分析了一套全球数据库，该库整合了1785种病毒与725种哺乳动物宿主的关联信息，数据来源于对1950年至2019年间已发表核苷酸序列附带元数据的自动筛查。

研究结果：基于当前已有证据，家养哺乳动物在已知哺乳动物-病毒互作网络中占据最核心的位置。