A pyroptosis and STING pathway dual activator potentiates the effects of radioimmunotherapy in TNBC

Radiotherapy is a cornerstone of triple-negative breast cancer (TNBC) treatment, yet clinical outcomes remain poor due to radioresistance. Although high expression of GSDMD and STING is correlated with better prognosis in TNBC patients, which was revealed from analysis of TNBC patient tissue microarrays, radiotherapy alone fails to adequately induce the upregulation.