Parameters of spatial orientations in the lipid bilayer of antimicrobial peptides.

The parameters were calculated by the PPM server.aDepth of the deepest non-hydrogen atom relative to position of membrane boundary located at the level of lipid carbonyl group.bAngle between membrane normal and main inertia axis of the molecule.cBinding energy (ΔGbinding) was calculated as the sum of the energy of peptide transfer from water to the lipid bilayer (ΔGtransfer) estimated by PPM and the folding energy (ΔGfolding) of an α-helix estimated by Framework; the folding energy of a β-hairpin stabilized by the disulfide was assumed to be zero.