An analysis of Gender Differences in American Indian and Alaskan Natives with Invasive Melanoma-Supplemental material

While gender strongly influences survival and presentation in melanoma, little is known about impact of gender in American Indians and Alaskan Natives (AI/AN). This study explored differences in tumor characteristics and survival between AI/AN males and females with invasive melanoma. Using the 2004-2018 National Cancer Database, a retrospective cohort study of AI/AN with primary invasive cutaneous melanoma was conducted. Statistical analysis included Mann-Whitney U (continuous variables), Chi-squared (categorical variables), Kaplan-Meier and log rank test (overall survival (OS)), and a multivariate Cox regression (independent survival predictors). Among AI/AN with invasive melanoma, women are diagnosed at an earlier age and stage, and they have better OS than men. Male gender is an independent predictor of worse OS. This dataset provides supplemental methods that were not able to be described in the research letter due to the limited word count. Additionally, we provide a figure that provides a detailed description of the case selection for this cohort of patients.

尽管性别对黑色素瘤（melanoma）的患者生存结局与临床表现具有显著影响，但目前学界对美洲印第安人与阿拉斯加原住民（American Indians and Alaskan Natives, AI/AN）群体中性别所产生的影响仍知之甚少。本研究针对罹患侵袭性黑色素瘤的AI/AN群体，探究了男女患者在肿瘤特征与生存结局方面的差异。本研究依托2004-2018年美国国家癌症数据库（National Cancer Database），针对原发性侵袭性皮肤黑色素瘤患者中的AI/AN人群开展了一项回顾性队列研究。本研究采用的统计学分析方法包括：用于连续变量的曼-惠特尼U检验（Mann-Whitney U test）、用于分类变量的卡方检验（Chi-squared test）、用于总生存期（overall survival, OS）分析的Kaplan-Meier法与log-rank检验，以及用于筛选生存预后独立影响因素的多因素Cox回归分析。在罹患侵袭性黑色素瘤的AI/AN人群中，女性患者的确诊年龄更早、临床分期更早，且总生存期优于男性；男性性别是总生存期不良的独立预后预测因素。由于本研究的研究信函受限于篇幅，未能完整呈现研究方法细节，本数据集补充提供了相关研究方法；此外，本数据集还附带一张详细说明本队列患者入组筛选流程的图表。