Crystal Structure of Chk2 in complex with an inhibitor

Crystal Structure of Chk2 in complex with an inhibitor Descriptor: 4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL, MAGNESIUM ION, NITRATE ION, ... Authors: Anderson, V.E, Walton, M.I, Eve, P.D, Caldwell, J.J, Pearl, L.H, Oliver, A.W, Collins, I, Garrett, M.D. Deposit date: 2010-04-12 Release date: 2011-01-12 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure-Based Design of Potent and Selective 2-(Quinazolin-2-Yl)Phenol Inhibitors of Checkpoint Kinase 2. J.Med.Chem., 54, 2011

检查点激酶2（Chk2）与抑制剂复合物的晶体结构 描述：该复合物组成包括4-氟-2-(4-{[(3S,4R)-4-(1-羟基-1-甲基乙基)吡咯烷-3-基]氨基}-6,7-二甲氧基喹唑啉-2-基)苯酚、镁离子、硝酸根离子等。作者：Anderson, V.E.、Walton, M.I.、Eve, P.D.、Caldwell, J.J.、Pearl, L.H.、Oliver, A.W.、Collins, I.、Garrett, M.D. 沉积日期：2010-04-12；发布日期：2011-01-12；最后修改日期：2023-12-20 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.3 Å） 引用文献：《强效且选择性的检查点激酶2（Chk2）2-(喹唑啉-2-基)苯酚类抑制剂的基于结构设计》，《药物化学杂志（J. Med. Chem.）》，54卷，2011年。