Data from: DualPhos: a versatile, chemoselective reagent for two-carbon aldehyde to latent (E)-alkenal homologation and application in the total synthesis of phomolide G

Advances on the use of the 2-pinacolacetal-tripropylphosphonium salt DualPhos as a general reagent for the two-carbon aldehyde to alkenal homologation and a chemoselective iron (III) chloride mediated deprotection are described. The strategy allows isolation of the latent alkenal intermediates or direct hydrolysis to (E)-alkenals. The robust chemical stability of the latent alkenals is demonstrated in a total synthesis of the macrolactone phomolide G.

本文报道了以2-频哪醇缩醛-三丙基鏻盐（DualPhos）作为通用试剂，用于两碳醛到烯醛的同系化反应，以及氯化铁(III)介导的化学选择性脱保护的研究进展。该策略既可分离得到潜在烯醛中间体，亦可直接水解得到(E)-型烯醛。本文通过大环内酯类天然产物phomolide G的全合成，证实了该潜在烯醛优异的化学稳定性。