Distinct cardiac transcriptomic clustering in titin and lamin a/c-associated dilated cardiomyopathy patients

RNA profiles strongly differ in TTNtv and LMNA-mutated DCM patients, despite clinical similarities as other pathogenic variant carriers such as RBM20 and MYH7, suggesting a specific genetic effect on the cardiac transcriptome in addition to the effect of the clinical component. Overall design: Comparing RNA-seq profiles of genetic DCM patients