Hazard ratios and 95% confidence intervals for the associations between FLG genotype and incident HPV-related disease.

Complete case analysis. Persons suffering from the cancer or disease of interest at baseline were excluded.$Adjusted for study and gender (age is underlying time axis). Not for cervical disease where only women were included.&Further adjusted for education, physical activity, smoking habits, alcohol intake, body mass index, systolic and diastolic blood pressure, serum triglycerides and HDL-cholesterol.* HPV-related cancers include cancer, cervix (ICD-7: 1711, 1712, ICD-10: C53), cancer, head and neck, subset (ICD-7: 1410, 1411, 1418, 1450, 1442, 1458, 1480, ICD-10: C01.9, C02.4, C02.8, C09.0, C09.1, C09.8, C09.9, C10.2, C10.8, C10.9, C14.0, C14.2, C14.8), cancer, vulva and vagina (ICD-7: 1760, 1761, 1762, 1763, 1765, ICD-10: C51, C52), cancer, penis (ICD-7: 1790, ICD-10: C60), and cancer, anus (ICD-7: No sufficiently specific ICD-7 code, ICD-10: C21.0-C21.8).** Cervical cancer, CIS and dysplasia include cancer, cervix (ICD-7: 1711, 1712, ICD-10: C53), CIS, cervix (ICD-7: 5710, 5711, ICD-10: D06), and dysplasia, cervix (ICD-7: 5712, ICD-10: N87).*** All HPV-related disease includes cancer, head and neck, subset (ICD-7: 1410, 1411, 1418, 1450, 1442, 1458, 1480, ICD-10: C01.9, C02.4, C02.8, C09.0, C09.1, C09.8, C09.9, C10.2, C10.8, C10.9, C14.0, C14.2, C14.8), cancer, vulva and vagina (ICD-7: 1760, 1761, 1762, 1763, 1765, ICD-10: C51, C52), cancer, penis (ICD-7: 1790, ICD-10: C60), cancer, anus (ICD-7: No sufficiently specific ICD-7 code, ICD-10: C21.0-C21.8), cancer, cervix (ICD-7: 1711, 1712, ICD-10: C53), CIS, cervix (ICD-7: 5710, 5711, ICD-10: D06), and dysplasia, cervix (ICD-7: 5712, ICD-10: N87).Abbreviations: CI, confidence interval; HR, hazard ratio, CIS, carcinoma in situ; HPV, human papillomavirus; FLG, filaggrin gene.