ELSA Polygenic Scores, 2022

 
<p>Polygenic scores (PGSs) are specific to each individual and represent an individual load for the common variants that are associated with a trait under study. They are increasingly used to predict disease risks.</p>
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<p>PGSs have been constructed for a number of behavioural, emotional and health-related phenotypes in the English Longitudinal Study of Ageing (ELSA) study (see the main ELSA study under
<a title="ELSA" href="https://beta.ukdataservice.ac.uk/datacatalogue/studies/study?id=5050">
SN 5050</a>). ELSA is a large, multidisciplinary study of cohort of men and women living in England aged 50 or over and representative of the English population both in terms of socioeconomic profile and geographic region. The methods employed for creating PGSs are those outlined by the US <a title="Health and Retirement Study" href="https://hrs.isr.umich.edu/about">
Health and Retirement Study</a> (HRS - not held at the UK Data Service). This was done in order to harmonise the research across age-related longitudinal studies by adopting a consistent methodology for creating PGSs. By making these PGSs publicly available, it is hoped that they will facilitate wide use among the ELSA data users.</p><p><span style="font-weight: bold;">Latest edition information:</span></p><p>For the second edition (November 2022), updated polygenic scores data and documentation were deposited.<br></p>

多基因评分（Polygenic Scores, PGSs）是针对每个个体特有的指标，代表与当前研究性状相关的常见变异在个体中的携带负荷，目前其在疾病风险预测中的应用日益广泛。

多基因评分已针对英国老龄化纵向研究（English Longitudinal Study of Ageing, ELSA）中的多种行为、情绪及健康相关表型构建完成（可通过SN 5050查阅ELSA核心研究详情，访问链接：https://beta.ukdataservice.ac.uk/datacatalogue/studies/study?id=5050）。ELSA是一项针对英格兰50岁及以上男性与女性群体的大型多学科队列研究，其在社会经济特征与地理分布层面均能代表英格兰整体人口。本研究构建多基因评分所采用的方法，参考了美国健康与退休研究（Health and Retirement Study, HRS——该数据集未由英国数据服务中心托管）所提出的流程。此举旨在通过统一的多基因评分构建方法，协调各年龄相关纵向研究间的研究标准。本次公开发布这些多基因评分，旨在助力ELSA数据集用户更广泛地使用相关资源。

**最新版本信息：**

2022年11月发布的第二版中，已更新多基因评分数据与配套文档并完成存档提交。

搜集汇总

背景与挑战

背景概述

该数据集是'ELSA Polygenic Scores, 2022'的第二版，由NatCen Social Research发布，包含更新后的多基因评分数据和文档。它作为英国数据服务的一部分，用于遗传学相关研究，但详情页未提供具体研究内容或变量信息。