Dataset from Sequential Optimization of Dose and Schedule of PfSPZ Vaccine, Verified by Randomized, Controlled, Double-blind Immunization and Controlled Human Malaria Infection in Malaria-naïve, Healthy Adult Volunteers in Germany
收藏NIAID Data Ecosystem2026-05-10 收录
下载链接：
https://doi.org/10.25934/PR00008040
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资源简介：
MAVACHE is a sequential dose and schedule optimization trial of intravenous immunization with
PfSPZ Vaccine in 18 to 54 malaria-naïve, healthy adult volunteers receiving 9x10^5,
1.35x10^6, or 2.7x10^6 PfSPZ per dose and a total dose between 2.7x10^6 and 8.1x10^6 PfSPZ
followed by CHMI with 3,200 fully infectious PfSPZ (PfSPZ Challenge).
PfSPZ Challenge (7G8) to assess vaccine efficacy, safety, tolerability and infectivity of
ascending PfSPZ doses will be assessed in healthy, malaria-naïve volunteers.
创建时间：
2026-02-06
