RNA sequencing on primary murine chondrocytes expressing mutant Idh1

Alliance of Genome Resources2026-08-01 收录

骨相关细胞转录组

IDH1基因突变

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http://www.informatics.jax.org/gxd/htexp_index/summary?arrayExpressID=GSE123130 数据链接链接失效反馈

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We report expression of a mutant Idh1 in murine chondrocytes caused a global change in the gene expression profile. mRNA profile of primary sternal chondrocytes from Col2a1Cre;Idh1 fl/fl mice and two control groups - Col2a1Cre and Idh1 fl/fl mice.

Loss of IDH1R132H mediated D-2HG production induces genome-wide demethylation in GCIMP low loci in patient-derived glioma cells

胶质瘤表观遗传学

IDH1基因突变

Here, we describe and characterize CRISPR-Cas9 based isogenic cell line models using patient-derived IDH1R132H/WT glioma cell lines, and we use these models to explore changes in DNA methylation follo

NIAID Data Ecosystem30

Transcriptome profile of RCS chondrocyte wt cell line and RCS chondrocyte obtained from a clone ko for the FGF receptors FGFR3 and FGFR4. Transcriptome profile of RCS chondrocyte wt cell line and RCS chondrocyte obtained from a clone ko for the FGF receptors FGFR3 and FGFR4

骨相关细胞转录组

FGF信号通路

To understand the transcriptomic effect of FGF18 treatment on Chondrocytes cells from wt rat and on Chondrocytes obtained from a clone ko for the FGF receptors FGFR3 and FGFR4, we performed Quant-seq

NIAID Data Ecosystem20

Expression profiles in wild-type and IDH1 R132H/WT human astroglial cells [RNA-seq]

IDH1基因突变

星形胶质细胞癌症前期机制

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are critical to oncogenesis. The exact mechanism by which mutant IDH1 drives cell transformation is still not fully understood, partially due t

NIAID Data Ecosystem10

RNA-Seq based analysis of chondroblasts subjected to general caspase inhibition revealed modulation of a spectrum of osteoarthritis related genes. RNA-Seq based analysis of chondroblasts subjected to general caspase inhibition revealed modulation of a spectrum of osteoarthritis related genes

关节炎分子机制

骨相关细胞转录组

Objective: The knowledge about functions of caspases, traditionally associated with cell death and inflammation, keeps expanding also regarding cartilage. Active caspases are expressed by chondrocytes

NIAID Data Ecosystem20

Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.

成骨分化分子机制

骨相关细胞转录组

The goal of this study was to assess changes in the mineralizing osteoblasts transcriptome upon TENT5A knockout in mice. Neonatal calvarial and adult long-bones osteoblasts were isolated from TENT5A K

NIAID Data Ecosystem10

RNA sequencing on primary murine chondrocytes expressing mutant Idh1

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