Gene expression data of bezafibrate treated CD8+ T cells

Activation of PPAR by bezafibrate synergize with PD-1 blockade. We found that PPAR activation enhanced the anti-apoptotic property of CD8+ T cells and increased its number in tumor site. PPAR target genes includes various genes associated with metabolic pathways. Using the microarray assay we found that fatty acid oxidation related genes and immune function related genes are involved in the enhnacement of antitumor immunity. Microarrays have been used to identify the genes, which include metabolic as well genes related to immune function, regulated by PPAR activation. We used in vitro system to identfy the genes. In vitro stimulated naive CD8+ T cells were treated with bezafibrate and DMSO. Cells were expanded in the presence of IL-2 and bezafibrate until day 13. We used two groups for analysis: Control (DMSO) and Treat (bezafibrate).