we performed a genome-wide synthetic lethal screen, using CRISPR-Cas9 genome editing, to identify potential therapeutic targets specific for ATRX-mutated cancers. In isogenic hepatocellular carcinoma
The top addressed synlet interactions based on sum of PubMed ID (PMID) counts as well as the respective novel proposed drug combinations are given in Table 1. Synlet interactions are sorted in descend
This file contains a list of queries used for trigenic interaction space extrapolation. The digenic interaction parameters used for binning for each double mutant query and its single mutant counterpa
This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.