Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus. Hypersensitive interferon responses in lupus keratinocytes reveal key mechanistic determinants in cutaneous lupus

SLE patients exhibit increased interferon signatures in their skin secondary to increased production and a robust, skewed IFN response that is regulated by PITX1. Targeting of these exaggerated pathways may prove to be beneficial to prevent and treat hyperinflammatory responses in SLE skin. Overall design: A cohort of 72 RNA-sequencing samples from 14 individuals (7 SLE and 7 healthy controls) was analyzed to study the transcriptomic effects of type I and type II IFNs on SLE vs. control keratinocytes.