Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment

We report the high-throughput sequencing of RNA expression in control embryos ,LoNA KO embryos, control 2c like mESC and LoNA KD 2c like mESC Overall design: Examination of RNA expression pattern in control embryos ,LoNA KO embryos, control 2c like mESC and LoNA KD 2c like mESC Examination of H3K27ac histone modifications and AcNPM1 pattern in control embryos ,LoNA KO embryos, LoNA KO embryos with P300 inhibitor treatment