Effects of pterostilbene on endothelial-to-mesenchymal transition in human primary pulmonary arterial endothelial cells

Pterostilbene is a stilbene compound originally isolated from the deciduous tree Pterocarpus marsupium native to India, which has a broad range of biological activities, including anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, and anti-tumor effects. Here we investigated the effects of pterostilbene on the endothelial-to-mesenchymal transition (EndMT) response induced in human primary pulmonary arterial endothelial cells in vitro.

紫檀芪（Pterostilbene）是一种二苯乙烯类化合物，最初从原产于印度的落叶乔木印度黄檀（Pterocarpus marsupium）中分离得到，其具备广泛的生物学活性，包括抗氧化、抗炎、降血糖、降血脂以及抗肿瘤等作用。本研究探究了紫檀芪对体外培养的原代人肺动脉内皮细胞（human primary pulmonary arterial endothelial cells）中所诱导的内皮细胞向间充质转化（EndMT）应答的影响。