MYSM1 deubiquitinates Histone H2A

MYSM1 is required for full activation of several transcriptional events, including androgen receptor (AR)-regulated target genes in prostate cancer cells. It is part of a regulatory protein complex with the histone acetyltransferase EP300 (p300) and KAT2B (CBP-associated factor (p/CAF)), regulating transcriptional initiation and elongaion by coordinating histone acetylation, H2A deubiquitination and linker histone dissociation. MYSM1 preferentially deubiquitinates H2A in hyperacetylated nucleosomes (Zhu et al. 2007).

MYSM1对于激活多种转录事件至关重要，包括在前列腺癌细胞中由雄激素受体（AR）调控的目标基因。MYSM1是组蛋白乙酰转移酶EP300（p300）和KAT2B（CBP关联因子，p/CAF）组成的调控蛋白复合体的一部分，通过协调组蛋白乙酰化、H2A去泛素化和连接组蛋白解离，调节转录的起始和延伸。MYSM1优先在高度乙酰化的核小体中去除H2A的泛素化（参见Zhu等，2007年）。