ERK2 covalently bound to RU67 cyclohexenone based inhibitor

ERK2 covalently bound to RU67 cyclohexenone based inhibitor Descriptor: AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{R})-4-oxidanylidene-1-(phenylmethyl)cyclohexane-1,3-dicarboxylate Authors: Sok, P, Poti, A, Remenyi, A, Gogl, G. Deposit date: 2023-07-13 Release date: 2024-07-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold. Nat Commun, 15, 2024

本数据集对应ERK2与RU67环己烯酮类抑制剂共价结合的复合物，描述符包括：AMP磷酰胺（AMP PHOSPHORAMIDATE）、丝裂原活化蛋白激酶1（Mitogen-activated protein kinase 1）以及(1R,3R)-4-氧代-1-(苄基)环己烷-1,3-二羧酸-1-甲基-3-叔丁基酯；作者为Sok P、Poti A、Remenyi A、Gogl G；存储日期2023-07-13，发布日期2024-07-24，最后修改日期2024-10-16；实验方法为X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å）；引用文献为《通过精准导向的弹头支架靶向丝裂原活化蛋白激酶的关键蛋白-蛋白相互作用界面》，发表于《自然-通讯》（Nat Commun）2024年第15卷。