Habitual coffee and caffeinated beverages consumption is inversely associated with arterial stiffness and central and peripheral blood pressure

The effects of chronic coffee consumption on the cardiovascular system are still under debate. Aortic stiffness, wave reflections, and central and peripheral blood pressure (BP) are milestone indicators of cardiovascular-risk. We sought to investigate the association between coffee and caffeine consumption, arterial stiffness, and central/peripheral BP. Aortic stiffness was evaluated via pulse wave velocity (PWV); wave reflections with the augmentation index (AIx);peripheral systolic BP (SBP), diastolic BP (DBP), and central BP (cSBP/cDBP) were non-invasively assessed. Coffee and caffeine consumption was ascertained using a questionnaire. A linear inverse relationship between coffee and caffeine consumption and arterial stiffness and central and peripheral BP was found.Light coffee and caffeine consumers showed β-coefficients for PWV–0.15, SBP–3.61, DBP–2.48, cSBP–3.21, and cDBP-2.18 (all p values < 0.05).Present findings suggest that coffee and caffeine consumption is inversely associated with arterial stiffness and central and peripheral BP in a large population sample. Interventional prospective studies are needed to demonstrate the causal association

长期饮用咖啡对心血管系统的影响尚存争议。主动脉僵硬度、脉搏波反射以及中心与外周血压（BP）均为心血管风险的关键评估指标。本研究旨在探究咖啡与咖啡因摄入、动脉僵硬度及中心/外周血压之间的关联。其中，通过脉搏波速度（PWV）评估主动脉僵硬度，采用增强指数（AIx）评估脉搏波反射；对外周收缩压（SBP）、外周舒张压（DBP）及中心血压（cSBP/cDBP）进行了非侵入性评估。咖啡与咖啡因摄入情况通过问卷进行采集。研究发现，咖啡与咖啡因摄入与动脉僵硬度及中心、外周血压呈线性负相关。轻度咖啡及咖啡因摄入人群的PWV β系数为-0.15、SBP为-3.61、DBP为-2.48、cSBP为-3.21、cDBP为-2.18（所有p值均<0.05）。本研究结果表明，在大样本人群中，咖啡与咖啡因摄入与动脉僵硬度及中心、外周血压呈负相关。未来需开展干预性前瞻性研究以证实二者间的因果关联。