Gene expression in human abdominal aortic aneurysm wall biopsie with high or low wall stress

This study investigates intra- and inter-individual RNA genome-wide expression profiling differences (Illumina HumanHT-12, BeadCHIP expression) of AAA (abdominal aortic aneurysms) biopsies from 12 patients. Biopsies were collected during open surgical AAA repair and according to prior finite element analysis (FEA) from regions with highest and lowest wall stress. Twenty-four (12 pairs) biopsies from 12 patients were analysed. RNA-profiles were pairwise (within individuals) compared, as well as between the two groups (high wall stress versus low wall stress).