Transcriptomic analysis of emergency granulopoiesis-generated neutrophils compared to steady state (control) neutrophils. Transcriptomic analysis of emergency granulopoiesis-generated neutrophils compared to steady state (control) neutrophils

Functional analysis demonstrates that neutrophils generated by emergency granulopoiesis have elevated bactericidal activity when compared to control (steady state) neutrophils. To determine if transcriptomic changes support these functional adaptations, we performed gene expression analysis on emergency granulopoiesis and steady state neutrophils before and after infection. Overall design: Differential gene expression analysis of RNA-seq data from neutrophils generated by steady state (control) granulopoiesis or emergency granulopoiesis either before or after infection in biological quadruplet.