Effect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P. Effect of PIM447 treatment on gene expression of M07e cells transduced with JAK3 Q988P

To test whether the activity of PIM proteins promotes an aberrant activation of the molecular cascades that are essential for the leukemogenic effects mediated by JAK/STAT pathway mutations, we analyzed RNA-seq data from M07e cells expressing JAK3Q988P that were treated with PIM447 or left untreated. Overall design: Comparative gene expression profiling analysis of RNA-seq data for M07e cells expressing JAK3Q988P that were treated with PIM447 or left untreated. Three replicates were used for each sample.