Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium

Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide, Renin Authors: Orth, P. Deposit date: 2015-01-29 Release date: 2015-02-18 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors. Bioorg. Med. Chem. Lett., 25, 2015

肾素（Renin）与(S)-1-(3-(苄基甲酰胺基)苄基)-4-异丙基-4-甲基-6-氧代四氢嘧啶-2(1H)-亚胺鎓（(S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium）形成的复合物。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、N-苄基-3-{[(2Z,4S)-2-亚氨基-4-甲基-6-氧代-4-(异丙基)四氢嘧啶-1(2H)-基]甲基}苯甲酰胺（N-benzyl-3-{[(2Z,4S)-2-imino-4-methyl-6-oxo-4-(propan-2-yl)tetrahydropyrimidin-1(2H)-yl]methyl}benzamide）、肾素。作者：Orth, P.。存储日期：2015-01-29；发布日期：2015-02-18；最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4 Å。引用文献：《亚胺嘧啶酮类：开发口服活性肾素抑制剂的新型药效团》，发表于《Bioorg. Med. Chem. Lett.》2015年第25卷。