Effect of Ifnar1 Knockdown in a mouse model of Cerebral Interferonopathy
收藏NIAID Data Ecosystem2026-05-01 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE231627
下载链接
链接失效反馈官方服务：
资源简介：
To investigate effect of antisense oligonucleotides targeting the murine IFNa receptor (Ifnar1 ASOs) in a transgenic mouse model of cerebral interferonopathy (GIFN), mice were injected intracerebroventricularly with Ifnar1 ASOs. We performed DGE-Seq on brain cortex samples to determine the impact of ASOs on the transcriptome. Treatment of GIFN mice with Ifnar1 ASOs resulted in a significant decrease in Interferon gene expression and dampened the hyperinflammatory transcriptomic landscape in the brains of GIFN mice. Comparative gene expression profiling analysis of transcriptome sequencing data for cortex samples from wildtype and transgenic mice treated with Ifnar1 ASOs or Vehicle.
创建时间：
2024-02-15
