Regio- and Enantioselective (Het)arylation of β‑Alkenyl Pyrroline to α‑Aryl-β-alkenyl Pyrrolidines
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资源简介：
Regio- and enantioselective direct arylation of β-alkenyl pyrroline is reported. A wide range of electron-rich arenes and heteroarenes reacted under mild conditions with different β-alkenyl pyrrolines to provide structurally diverse α-aryl-β-alkenyl pyrrolidines with very good yields and excellent regioselectivity. Enantioselective reaction in the presence of Lewis acids and chiral phosphoric acids provided the desired arylated product with 73% enantiomeric excess.
创建时间：
2019-01-31
