NRIF binds to p75NTR

NRIF is a ubiquitously expressed zinc finger protein of the Kruppel family that may transduce cell death signals during development and functions in association with TRAF6 to induce activation of JNK. NRIF-induced cell death through p75NTR requires p53 and NRIF nuclear translocation, which is modulated by TRAF6-mediated polyubiquitination of NRIF at lysine 63.

NRIF是一种在发育过程中广泛表达的Kruppel家族锌指蛋白，可能转化细胞死亡信号，并伴随TRAF6的功能，诱导JNK的激活。NRIF通过p75NTR诱导的细胞死亡需要p53和NRIF的核转位，这一过程受到TRAF6介导的NRIF在赖氨酸63位的泛素化的调节。