The C-terminus of CBFß-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis.
收藏官方服务:
资源简介:
The C-terminus of CBFß-SMMHC is required to induce embryonic hematopoietic defects and leukemogenesis.
应用场景:
创建时间:
2013-02-19
相关数据集
Ezh2 and Runx1 Mutations Targeted to Early Lymphoid Progenitors Collaborate to Promote Early Thymic Progenitor Leukemia [ChIP-Seq]
Understanding the specific cell populations responsible for propagation of leukemia is an important step for development of effective targeted therapies. Recently, the lymphoid-primed multipotent prog
NIAID Data Ecosystem80
Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]
MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA
NIAID Data Ecosystem30
Acute myeloid leukemia cells functionally compromise hematopoietic stem/progenitor cells inhibiting normal hematopoiesis through the release of extracellular vesicles. Acute myeloid leukemia cells functionally compromise hematopoietic stem/progenitor cells inhibiting normal hematopoiesis through the release of extracellular vesicles
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal disorder of hematopoietic stem/progenitor cells (HSPCs). It is not well known how leukemia cells alter hematopoiesis promoting tu
NIAID Data Ecosystem20
ChIP-seq BigWig signal tracks for genome-wide chromatin profiling in CD34+ PB-HSPCs and
These bigWig files contain normalized ChIP-seq signal tracks generated from CD34+ PB-HSPCs and in vitro differentiated megakaryocytes and monocytes. The data represent genome-wide binding profiles of
NIAID Data Ecosystem40
Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [ChIP-Seq]. Single cell analysis reveals mechanisms of heterogeneity and plasticity of leukemia initiating cells [ChIP-Seq]
Leukemia initiating cells (LICs) self-renew indefinitely to fuel leukemic growth and spark disease relapse. Previously thought to be primitive and rare, the LIC state may actually be heterogeneous and
NIAID Data Ecosystem30



