The Cancer Genome Atlas Thyroid Cancer Collection (TCGA-THCA)

The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.

癌症基因组图谱甲状腺癌（The Cancer Genome Atlas Thyroid Cancer, TCGA-THCA）数据集是一项更大规模研究计划的组成部分，该计划旨在构建一个聚焦于通过为癌症基因组图谱（The Cancer Genome Atlas, TCGA）受试者匹配临床影像，从而关联癌症表型与基因型的研究共同体。临床、遗传与病理数据存储于基因组数据共享库（Genomic Data Commons, GDC）数据门户，而放射影像数据则留存于癌症影像档案库（The Cancer Imaging Archive, TCIA）。匹配的TCGA患者标识符可供研究人员在TCGA与TCIA数据库中探索组织基因型、放射影像表型与患者预后之间的相关性。TCGA的组织样本采集自全球多个站点，以达成每类癌症约500份标本的入组目标。正因如此，该影像数据集在扫描模态、设备厂商与采集协议方面均存在显著异质性。在多数情况下，这些影像属于常规诊疗环节的采集产物，而非受控研究或临床试验的一部分。