Spaceflight induces systemic effects on extracellular matrix and immune system in different age-stages

Spaceflights significantly impacts astronaut health, causing muscle atrophy, bone loss, cardiovascular deconditioning and immune system dysregulation, especially during long missions. To explore molecular changes, we generated a single-cell RNA sequencing dataset, of 216 samples from 28 mouse organs and tissues under spaceflight and control conditions. Since spaceflight effects closely resemble aspects of aging, we included two age groups (3 and 8 months) to assess age-related influences.