Unique loci that influence the NMR-metabolome.

*Also associated to creatine (P-value  =  1.40×10−8). MD; major depression, CD; Crohn's disease, MetS; metabolic syndrome, CHD; coronary heart disease. CRP; C-reactive protein, eGFR; glomerular filtration rate, PWV, pulse wave velocity. Phenotypes are shown that are associated with loci reported in GWAS catalog [22] and that lie within a 500 kb window of the main locus, regardless of linkage disequilibrium. Candidate genes 500 kb window around the best associated SNP were selected by automated workflow based on metabolic pathway information (see methods). eQTL lookups were perfomed in GTEX and GEUVADIS databases. Chr; chromosome; MAF; minor allele frequency; SNP; single nucleotide polymorphism; R2; Explained variance in metabolite level by the top SNP, eQTL; expression quantitative trait loci.
Unique loci that influence the NMR-metabolome.