Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with UDP and biantennary pentasaccharide M592

Protein Data Bank Japan2024-10-23 更新2026-03-21 收录

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Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with UDP and biantennary pentasaccharide M592 Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose, ... Authors: Wu, L, Darby, J.F, Gilio, A.K, Davies, G.J. Deposit date: 2020-04-04 Release date: 2020-08-05 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V Acs Catalysis, 2020

MGAT5（α-1,6-甘露糖蛋白6-β-N-乙酰葡糖胺转移酶V，alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V）带有Lys329-Ile345环截短的腔内结构域，与尿苷二磷酸（UDP）及双天线五糖M592形成复合物的晶体结构。配体描述：1,2-乙二醇，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)-[α-D-吡喃甘露糖-(1→3)]α-D-吡喃甘露糖，…… 作者：Wu, L、Darby, J.F.、Gilio, A.K.、Davies, G.J. 提交日期：2020-04-04 发布日期：2020-08-05 最后修改日期：2024-10-23 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.96埃（Å）引用文献：《N-乙酰葡糖胺转移酶V的底物结合与催化机制》，发表于Acs Catalysis，2020年

创建时间：

2020-04-04