Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
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Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site Descriptor: (5R)-5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... Authors: Yang, J, Campobasso, N, Biju, M.P, Fisher, K, Pan, X.Q, Cottom, J, Galbraith, S, Ho, T, Zhang, H, Hong, X, Ward, P, Hofmann, G, Siegfried, B. Deposit date: 2010-12-13 Release date: 2011-03-09 Last modified: 2025-05-07 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site. Chem.Biol., 18, 2011
结合于肉豆蔻酰结合位点（Myristoyl Binding Site）的具有细胞穿透性的小分子c-Abl激酶激活剂的发现与表征
描述：(5R)-5-[3-(4-氟苯基)-1-苯基-1H-吡唑-4-基]咪唑烷-2,4-二酮、4-(4-甲基哌嗪-1-基甲基)-N-[4-甲基-3-(4-吡啶-3-基嘧啶-2-基氨基)苯基]苯甲酰胺、甘油等。
作者：Yang, J、Campobasso, N、Biju, M.P、Fisher, K、Pan, X.Q、Cottom, J、Galbraith, S、Ho, T、Zhang, H、Hong, X、Ward, P、Hofmann, G、Siegfried, B
存储日期：2010-12-13
发布日期：2011-03-09
最后修改日期：2025-05-07
研究方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.85埃
引用文献：《结合于肉豆蔻酰结合位点的具有细胞穿透性的小分子c-Abl激酶激活剂的发现与表征》，发表于*Chem.Biol.*，第18卷，2011年
创建时间：
2010-12-13
